The increased importance private and public institutions place on Ethical, Legal and Social Implications (ELSI) research and Diversity, Equity and Inclusion (DEI) has led to a growing interest to include scholars perceived to have expertise in ethics in STEM research. However, little attention has been paid to best practices for fostering their integration into research teams, or for evaluating its effects. What counts as “embedded” or “integrated” ELSI, or DEI work, is not clearly defined. Additionally, no clear guidelines exist to determine if the inclusion of ELSI and DEI specialists leads to more inclusive, ethical and just outcomes. This lack of guidance has led to a number of critical debates and raised fundamental questions: (1) Who should speak for ELSI and identify ELSI questions within biomedical research (e.g. members of affected communities, scientists, social scientists, philosophers, etc.)?; (2) What counts as ELSI research and how should ELSI be integrated (e.g. stand-alone, integrated or embedded) and evaluated?; and (3) Who is responsible for DEI and how should DEI objectives be measured, evaluated, and managed? This workshop will begin with brief presentations on the challenges of integrating ethics into biomedical research and the need for a multi-institutional, multi-disciplinary effort towards Leadership in the Equitable and Ethical Design of Science and Engineering (LEED). Participants will be invited to engage in discussion on the meaning of “integration” and “embedded” ELSI and DEI efforts in small breakout groups that will include specific fields of inquiry such as genomics, neuroscience and artificial intelligence.